exclude individual user profile folders

Requesting a way to create a folder exclusion that would apply to any user’s profile folder (C:\users\USERNAME\appdata\...) that logs into a PC.  The USERNAME will be different for each user.

i.e.: c:\users\reception\appdata\local\, c:\users\jsmith\appdata\local

in windows we would script this as c:\users\%username%\appdata\local

There is not a way to do this in SEP cloud unless I list out each users profile folder which is not viable